ATF7 iso1 Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation. Belongs to the bZIP family. Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 15|15 F3
Cellular Component:  nuclear periphery
Molecular Function:  DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; mitogen-activated protein kinase binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription factor binding
Biological Process:  negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  Q8R0S1 (UniProtKB)
Alt. Names/Synonyms: 1110012F10Rik; 9430065F09Rik; Activating transcription factor 7; AI549878; Atf7; ATF7 iso1; C130020M04Rik; cAMP-dependent transcription factor ATF-7; Cyclic AMP-dependent transcription factor ATF-7; MGC31554; Transcription factor ATF-A
Gene Symbols: Atf7
Molecular weight: 44,608 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
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ATF7 iso1

Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene