ATF7 iso1 Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]- 3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Belongs to the bZIP family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 15|15 F3
Cellular Component:  nuclear periphery
Molecular Function:  DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; mitogen-activated protein kinase binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription factor binding
Biological Process:  negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  Q8R0S1 (UniProtKB)
Alt. Names/Synonyms: 1110012F10Rik; 9430065F09Rik; Activating transcription factor 7; AI549878; Atf7; C130020M04Rik; cAMP-dependent transcription factor ATF-7; Cyclic AMP-dependent transcription factor ATF-7; MGC31554; Transcription factor ATF-A
Gene Symbols: Atf7
Molecular weight: 44,608 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
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ATF7 iso1

Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene