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RANBP9
May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. Belongs to the RANBP9/10 family. Ubiquitously expressed, with highest levels in testes, placenta, heart, and muscle, and lowest levels in lung. Within the brain, expressed predominantly by neurons in the gray matter of cortex, the granular layer of cerebellum and the Purkinje cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; GAP; GAP, Ras; Nuclear receptor co-regulator |
| Chromosomal Location of human Ortholog: 6p23 |
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Cellular Component:
cytoplasm; cytosol; microtubule associated complex; nuclear body; nucleoplasm; nucleus; plasma membrane; ubiquitin ligase complex
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Molecular Function:
enzyme binding; protein binding; small GTPase binding
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Biological Process:
cytoskeleton organization; microtubule nucleation; negative regulation of ERK1 and ERK2 cascade; positive regulation of amyloid precursor protein catabolic process; protein-containing complex assembly
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Reference #:
Q96S59
(UniProtKB)
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Alt. Names/Synonyms: BPM-L; BPM90; novel centrosomal protein RanBPM; RAN binding protein 9; Ran Binding Protein in the Microtubule organizing center; ran binding protein, centrosomal; Ran-binding protein 9; Ran-binding protein M; RANB9; RanBP7; RANBP9; RANBPM
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Gene Symbols: RANBP9
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Molecular weight:
77,847 Da
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Basal Isoelectric point:
6.31
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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