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ATP11C
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. In the cell membrane of erythrocytes, it is required to maintain phosphatidylserine (PS) in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for splenic macrophages. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate PS flipping in pro-B cells. May be involved in the transport of cholestatic bile acids. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. Widely expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.3.1; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel |
| Chromosomal Location of human Ortholog: Xq27.1 |
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Cellular Component:
early endosome membrane; endoplasmic reticulum; endoplasmic reticulum membrane; phospholipid-translocating ATPase complex; plasma membrane; recycling endosome; recycling endosome membrane
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Molecular Function:
ATP binding; ATP hydrolysis activity; ATPase-coupled intramembrane lipid transporter activity; magnesium ion binding; phosphatidylethanolamine flippase activity; phosphatidylserine flippase activity; phosphatidylserine floppase activity; protein binding
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Biological Process:
aminophospholipid translocation; monoatomic ion transmembrane transport; phospholipid translocation
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Disease: Hemolytic Anemia, Congenital, X-linked
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Reference #:
Q8NB49
(UniProtKB)
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Alt. Names/Synonyms: AT11C; ATP11C; ATPase class VI type 11C; ATPase IQ; ATPase phospholipid transporting 11C; ATPase, class VI, type 11C; ATPIG; ATPIQ; HACXL; P4-ATPase flippase complex alpha subunit ATP11C; Phospholipid-transporting ATPase IG; Probable phospholipid-transporting ATPase IG
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Gene Symbols: ATP11C
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Molecular weight:
129,477 Da
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Basal Isoelectric point:
6.25
Predict pI for various phosphorylation states
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