CHD-6 DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. Belongs to the SNF2/RAD54 helicase family. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC 3.6.4.12; Helicase
Chromosomal Location of mouse Ortholog: 2|2 H2
Cellular Component:  chromatin; nucleoplasm; nucleus
Molecular Function:  ATP binding; ATP hydrolysis activity; ATP-dependent activity, acting on DNA; ATP-dependent chromatin remodeler activity; chromatin binding; DNA binding; helicase activity; histone binding; hydrolase activity; nucleotide binding; transcription coregulator binding
Biological Process:  cell redox homeostasis; chromatin organization; chromatin remodeling; positive regulation of transcription by RNA polymerase II; regulation of gene expression
Reference #:  A3KFM7 (UniProtKB)
Alt. Names/Synonyms: 4930532L22Rik; 5430439G14Rik; 6330406J24Rik; ATP-dependent helicase CHD6; AW060752; B230399N07Rik; CHD-6; Chd5; CHD6; chromodomain helicase DNA binding protein 5; chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6; Kiaa1335
Gene Symbols: Chd6
Molecular weight: 305,397 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below

CHD-6

Protein Structure Not Found.


Cross-references to other databases:  BioGPS  |  Pfam  |  ENZYME  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein