GBP1 Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Hydrolase; Vesicle
Chromosomal Location of human Ortholog: 1p22.2
Cellular Component:  actin cytoskeleton; cytoplasm; cytosol; extracellular region; Golgi apparatus; Golgi membrane; plasma membrane; vesicle membrane
Molecular Function:  actin binding; cytokine binding; enzyme binding; GDP binding; GTP binding; GTPase activity; Hsp90 protein binding; identical protein binding; protein binding; protein homodimerization activity; spectrin binding
Biological Process:  cellular response to interferon-gamma; cellular response to interleukin-1; cellular response to tumor necrosis factor; defense response to virus; interferon-gamma-mediated signaling pathway; negative regulation of ERK1 and ERK2 cascade; negative regulation of interleukin-2 secretion; negative regulation of protein localization to plasma membrane; negative regulation of substrate adhesion-dependent cell spreading; negative regulation of T cell receptor signaling pathway; protein homooligomerization; protein localization to vacuole; regulation of calcium-mediated signaling; regulation of protein localization to plasma membrane
Reference #:  P32455 (UniProtKB)
Alt. Names/Synonyms: GBP-1; GBP1; GTP-binding protein 1; Guanine nucleotide-binding protein 1; guanylate binding protein 1; guanylate binding protein 1, interferon-inducible, 67kDa; Guanylate-binding protein 1; HuGBP-1; Interferon-induced guanylate-binding protein 1
Gene Symbols: GBP1
Molecular weight: 67,931 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene