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GBP1
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Hydrolase; Vesicle |
| Chromosomal Location of human Ortholog: 1p22.2 |
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Cellular Component:
actin cytoskeleton; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; extracellular region; Golgi apparatus; Golgi membrane; plasma membrane; symbiont cell surface; vesicle membrane
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Molecular Function:
actin binding; cytokine binding; enzyme binding; G protein activity; GDP binding; GDP phosphatase activity; GTP binding; GTPase activity; Hsp90 protein binding; identical protein binding; protein binding; protein homodimerization activity; spectrin binding
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Biological Process:
cellular response to interleukin-1; cellular response to tumor necrosis factor; cellular response to type II interferon; cytolysis in another organism; defense response to bacterium; defense response to protozoan; defense response to virus; innate immune response; negative regulation of ERK1 and ERK2 cascade; negative regulation of interleukin-2 production; negative regulation of protein localization to plasma membrane; negative regulation of substrate adhesion-dependent cell spreading; negative regulation of T cell receptor signaling pathway; non-canonical inflammasome complex assembly; positive regulation of pyroptosis; protein localization to vacuole; regulation of calcium-mediated signaling; regulation of protein localization to plasma membrane
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Reference #:
P32455
(UniProtKB)
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Alt. Names/Synonyms: GBP-1; GBP1; GTP-binding protein 1; Guanine nucleotide-binding protein 1; guanylate binding protein 1; guanylate binding protein 1, interferon-inducible, 67kDa; Guanylate-binding protein 1; HuGBP-1; Interferon-induced guanylate-binding protein 1
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Gene Symbols: GBP1
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Molecular weight:
67,931 Da
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Basal Isoelectric point:
5.97
Predict pI for various phosphorylation states
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