BRAP Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. Expressed in breast epithelial cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 12q24.12
Cellular Component:  cytoplasm; cytosol; nuclear membrane; ubiquitin ligase complex
Molecular Function:  identical protein binding; nuclear localization sequence binding; nucleic acid binding; protein binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding
Biological Process:  MAPK cascade; negative regulation of signal transduction; protein ubiquitination; Ras protein signal transduction
Reference #:  Q7Z569 (UniProtKB)
Alt. Names/Synonyms: BRAP; BRAP2; BRCA1 associated protein; BRCA1-associated protein; galectin-2-binding protein; IMP; Impedes mitogenic signal propagation; Renal carcinoma antigen NY-REN-63; RING finger protein 52; RING-type E3 ubiquitin transferase BRAP2; RNF52
Gene Symbols: BRAP
Molecular weight: 67,305 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
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Protein Structure Not Found.

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