|
BRAP
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. Expressed in breast epithelial cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of Human Ortholog: 12q24.12 |
|
Cellular Component:
cytoplasm; cytosol; nuclear membrane; ubiquitin ligase complex
|
|
Molecular Function:
identical protein binding; nuclear localization sequence binding; nucleic acid binding; protein binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding
|
|
Biological Process:
MAPK cascade; negative regulation of signal transduction; protein ubiquitination; Ras protein signal transduction
|
|
Reference #:
Q7Z569
(UniProtKB)
|
|
Alt. Names/Synonyms: BRAP; BRAP2; BRCA1 associated protein; BRCA1-associated protein; galectin-2-binding protein; IMP; Impedes mitogenic signal propagation; Renal carcinoma antigen NY-REN-63; RING finger protein 52; RING-type E3 ubiquitin transferase BRAP2; RNF52
|
|
Gene Symbols: BRAP
|
|
Molecular weight:
67,305 Da
|
|
Basal Isoelectric point:
5.64
Predict pI for various phosphorylation states
|
|
CST Pathways:
GPCR Signaling to MAPKs
|
Growth And Differentiation Control by MAPKs
|
