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TOPBP1
Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR. Highly expressed in heart, brain, placenta, lung and kidney. Note: This description may include information from UniProtKB.
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| Protein type: DNA replication |
| Chromosomal Location of human Ortholog: 3q22.1 |
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Cellular Component:
actin cytoskeleton; BRCA1-B complex; chromosome; condensed nuclear chromosome; cytoplasm; male germ cell nucleus; microtubule organizing center; nuclear body; nucleoplasm; nucleus; plasma membrane; PML body; spindle pole
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Molecular Function:
DNA binding; identical protein binding; protein binding
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Biological Process:
DNA damage response; DNA metabolic process; DNA repair; DNA replication initiation; homologous recombination; mitotic DNA replication checkpoint signaling; mitotic G2 DNA damage checkpoint signaling; response to ionizing radiation
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Reference #:
Q92547
(UniProtKB)
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Alt. Names/Synonyms: DNA topoisomerase 2-binding protein 1; DNA topoisomerase II binding protein 1; DNA topoisomerase II-beta-binding protein 1; DNA topoisomerase II-binding protein 1; Dpb11; KIAA0259; TOP2BP1; TOPB1; TOPBP1; topoisomerase (DNA) II binding protein 1
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Gene Symbols: TOPBP1
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Molecular weight:
170,679 Da
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Basal Isoelectric point:
6.52
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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