TDP1 DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. Belongs to the tyrosyl-DNA phosphodiesterase family. Ubiquitously expressed. Similar expression throughout the central nervous system (whole brain, amygdala, caudate nucleus, cerebellum, cerebral cortex, frontal lobe, hippocampus, medulla oblongata, occipital lobe, putamen, substantia nigra, temporal lobe, thalamus, nucleus accumbens and spinal cord) and increased expression in testis and thymus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: DNA repair, damage; EC 3.1.4.-; Phosphodiesterase

Chromosomal Location of human Ortholog: 14q32.11

Cellular Component: cytoplasm; intracellular membrane-bounded organelle; nucleoplasm; nucleus; plasma membrane

Molecular Function: 3'-tyrosyl-DNA phosphodiesterase activity; double-stranded DNA binding; exonuclease activity; protein binding; single-stranded DNA binding

Biological Process: DNA repair; double-strand break repair; nucleic acid phosphodiester bond hydrolysis; single strand break repair

Disease: Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy

Reference #: Q9NUW8 (UniProtKB)

Alt. Names/Synonyms: FLJ11090; MGC104252; TDP1; TYDP1; Tyr-DNA phosphodiesterase 1; Tyrosyl-DNA phosphodiesterase 1

Gene Symbols: TDP1

Molecular weight: 68,420 Da

Basal Isoelectric point: 7.34 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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TDP1

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