RGS19 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 Highest expression in lung. Placenta, liver and heart also express high levels of GAIP. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, RGS
Chromosomal Location of human Ortholog: 20q13.33
Cellular Component:  brush border; clathrin-coated vesicle; Golgi apparatus; membrane; membrane raft; plasma membrane
Molecular Function:  G-protein alpha-subunit binding; GTPase activity; protein binding
Biological Process:  autophagy; G protein-coupled receptor signaling pathway; negative regulation of signal transduction; response to ethanol; small GTPase mediated signal transduction
Reference #:  P49795 (UniProtKB)
Alt. Names/Synonyms: G alpha interacting protein; G protein signalling regulator 19; G-alpha-interacting protein; GAIP; GNAI3IP; guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein; regulator of G protein signaling 19; Regulator of G-protein signaling 19; regulator of G-protein signalling 19; RGS19; RGSGAIP
Gene Symbols: RGS19
Molecular weight: 24,636 Da
Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein