RGS19
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 Highest expression in lung. Placenta, liver and heart also express high levels of GAIP. Note: This description may include information from UniProtKB.
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Protein type: GAP; GAP, RGS |
Chromosomal Location of human Ortholog: 20q13.33 |
Cellular Component:
brush border; clathrin-coated vesicle; Golgi apparatus; membrane; plasma membrane
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Molecular Function:
G-protein alpha-subunit binding; GTPase activity; protein binding
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Biological Process:
autophagy; G protein-coupled receptor signaling pathway; negative regulation of signal transduction; response to ethanol; small GTPase mediated signal transduction
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Reference #:
P49795
(UniProtKB)
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Alt. Names/Synonyms: G alpha interacting protein; G protein signalling regulator 19; G-alpha-interacting protein; GAIP; GNAI3IP; guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein; regulator of G protein signaling 19; Regulator of G-protein signaling 19; regulator of G-protein signalling 19; RGS19; RGSGAIP
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Gene Symbols: RGS19
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Molecular weight:
24,636 Da
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Basal Isoelectric point:
5.43
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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