ILF2 Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component:  extracellular region; ficolin-1-rich granule lumen; nucleolus; nucleus; ribonucleoprotein complex; specific granule lumen; tertiary granule lumen
Molecular Function:  ATP binding; DNA binding; double-stranded RNA binding; protein binding; transferase activity
Biological Process:  neutrophil degranulation; positive regulation of transcription, DNA-templated; transcription, DNA-templated
Reference #:  Q12905 (UniProtKB)
Alt. Names/Synonyms: ILF2; interleukin enhancer binding factor 2; interleukin enhancer binding factor 2, 45kD; interleukin enhancer binding factor 2, 45kDa; Interleukin enhancer-binding factor 2; MGC8391; NF45; Nuclear factor of activated T-cells 45 kDa; nuclear factor of activated T-cells, 45-kDa; PRO3063
Gene Symbols: ILF2
Molecular weight: 43,062 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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