MFGE8 Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization. Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Medin is the main constituent of aortic medial amyloid. Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of mouse Ortholog: 7 D2|7 44.9 cM
Cellular Component:  cytoplasmic vesicle; external side of plasma membrane; extracellular region; extracellular space; membrane
Molecular Function:  extracellular matrix structural constituent; integrin binding; phosphatidylserine binding
Biological Process:  angiogenesis; apoptotic cell clearance; cell adhesion; single fertilization
Reference #:  P21956 (UniProtKB)
Alt. Names/Synonyms: AA408458; AI325141; EGF/factor VIII; lacta; Lactadherin; MFG-E8; Mfge8; MFGM; milk fat globule glycoprotein; Milk fat globule-EGF factor 8; milk fat globule-EGF factor 8 protein; MP47; P47; SED; SED1; Sperm surface protein SP47
Gene Symbols: Mfge8
Molecular weight: 51,241 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene