PSMD7 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Belongs to the peptidase M67A family. Note: This description may include information from UniProtKB.
Protein type: Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 16q23.1
Cellular Component:  cytosol; extracellular region; ficolin-1-rich granule lumen; nucleoplasm; proteasome complex; proteasome regulatory particle; secretory granule lumen
Molecular Function:  protein binding; protein homodimerization activity
Biological Process:  anaphase-promoting complex-dependent catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; Fc-epsilon receptor signaling pathway; interleukin-1-mediated signaling pathway; MAPK cascade; negative regulation of canonical Wnt signaling pathway; negative regulation of G2/M transition of mitotic cell cycle; neutrophil degranulation; NIK/NF-kappaB signaling; positive regulation of canonical Wnt signaling pathway; post-translational protein modification; proteasome-mediated ubiquitin-dependent protein catabolic process; protein deubiquitination; protein polyubiquitination; regulation of cellular amino acid metabolic process; regulation of hematopoietic stem cell differentiation; regulation of mitotic cell cycle phase transition; regulation of mRNA stability; regulation of transcription from RNA polymerase II promoter in response to hypoxia; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; transmembrane transport; tumor necrosis factor-mediated signaling pathway; Wnt signaling pathway, planar cell polarity pathway
Reference #:  P51665 (UniProtKB)
Alt. Names/Synonyms: 26S proteasome non-ATPase regulatory subunit 7; 26S proteasome regulatory subunit rpn8; 26S proteasome regulatory subunit S12; Moloney leukemia virus-34 proviral integration; MOV34; Mov34 homolog; Mov34 protein homolog; MOV34L; P40; proteasome (prosome, macropain) 26S subunit, non-ATPase, 7; proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog); proteasome 26S non-ATPase subunit 7; Proteasome subunit p40; PSD7; PSMD7; Rpn8; S12
Gene Symbols: PSMD7
Molecular weight: 37,025 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
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PSMD7

Protein Structure Not Found.


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