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MAF1
Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance. Plays also a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation. Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB. When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout. Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP. Belongs to the MAF1 family. Note: This description may include information from UniProtKB.
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| Protein type: Transcription regulation |
| Chromosomal Location of mouse Ortholog: 15|15 D3 |
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Cellular Component:
axon; cytoplasm; cytosol; dendrite; inhibitory synapse; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane
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Molecular Function:
GABA receptor binding; RNA polymerase III core binding; RNA polymerase III type 1 promoter sequence-specific DNA binding; RNA polymerase III type 2 promoter sequence-specific DNA binding; RNA polymerase III type 3 promoter sequence-specific DNA binding
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Biological Process:
negative regulation of transcription by RNA polymerase I; negative regulation of transcription by RNA polymerase III
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Reference #:
Q9D0U6
(UniProtKB)
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Alt. Names/Synonyms: 1110068E11Rik; AU042856; Maf; Maf1; MAF1 homolog (S. cerevisiae); MAF1 homolog, negative regulator of RNA polymerase III; Repressor of RNA polymerase III transcription MAF1 homolog
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Gene Symbols: Maf1
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Molecular weight:
28,780 Da
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Basal Isoelectric point:
4.55
Predict pI for various phosphorylation states
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