Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Interacts with POLR2A phosphorylated at 'Ser-5', but not with the unphosphorylated, nor 'Ser-2' phosphorylated POLR2A forms. Interacts with FANCD2 and DBF4. Interacts with JUND. Interacts with SMAD3, but not with SMAD2, nor SMAD4. Directly interacts with NFKB1, NFKB2 and RELA. Ubiquitous. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Molecular Function: chromatin binding; DNA binding; double-stranded DNA binding; four-way junction DNA binding; protein binding; protein binding, bridging; protein N-terminus binding; R-SMAD binding; sequence-specific DNA binding; transcription regulatory region DNA binding; Y-form DNA binding
Biological Process: cell cycle arrest; cellular response to DNA damage stimulus; chromatin organization; chromatin remodeling; embryonic skeletal system morphogenesis; hemopoiesis; histone methylation; leukocyte homeostasis; MAPK cascade; maternal process involved in female pregnancy; negative regulation of cell cycle; negative regulation of cell cycle G1/S phase transition; negative regulation of cell proliferation; negative regulation of cell-substrate adhesion; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of DNA-binding transcription factor activity; negative regulation of epithelial cell proliferation; negative regulation of JNK cascade; negative regulation of organ growth; negative regulation of osteoblast differentiation; negative regulation of protein phosphorylation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; ossification; osteoblast development; osteoblast fate commitment; positive regulation of apoptotic process; positive regulation of cell differentiation; positive regulation of cell division; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of gene expression; positive regulation of histone methylation; positive regulation of osteoblast differentiation; positive regulation of protein binding; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of activin receptor signaling pathway; regulation of gene expression; regulation of type B pancreatic cell proliferation; response to gamma radiation; response to transforming growth factor beta; response to UV; roof of mouth development; type B pancreatic cell differentiation