MEN1 Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of mouse Ortholog: 19|19 A
Cellular Component:  chromatin; chromosome, telomeric region; cleavage furrow; cytoplasm; cytosol; histone methyltransferase complex; MLL1 complex; MLL1/2 complex; nuclear matrix; nucleoplasm; nucleus; protein-containing complex; transcription repressor complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity; double-stranded DNA binding; four-way junction DNA binding; phosphoprotein binding; protein binding; protein-macromolecule adaptor activity; R-SMAD binding; sequence-specific DNA binding; transcription cis-regulatory region binding; Y-form DNA binding
Biological Process:  cell division; cell population proliferation; chromatin organization; chromatin remodeling; DNA damage response; embryo development; embryonic skeletal system morphogenesis; fibroblast apoptotic process; fibroblast proliferation; hemopoiesis; leukocyte homeostasis; MAPK cascade; maternal process involved in female pregnancy; negative regulation of cell cycle; negative regulation of cell cycle G1/S phase transition; negative regulation of cell population proliferation; negative regulation of cell-substrate adhesion; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of epithelial cell proliferation; negative regulation of fibroblast proliferation; negative regulation of JNK cascade; negative regulation of organ growth; negative regulation of osteoblast differentiation; negative regulation of protein phosphorylation; negative regulation of stem cell proliferation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of type B pancreatic cell proliferation; organ growth; ossification; osteoblast development; osteoblast fate commitment; positive regulation of cell division; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA-templated transcription; positive regulation of fibroblast apoptotic process; positive regulation of gene expression; positive regulation of osteoblast differentiation; positive regulation of stem cell differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of activin receptor signaling pathway; regulation of G1/S transition of mitotic cell cycle; regulation of gene expression; regulation of transcription by RNA polymerase II; regulation of type B pancreatic cell proliferation; response to gamma radiation; response to transforming growth factor beta; response to UV; roof of mouth development; stem cell differentiation; stem cell proliferation; T-helper 2 cell differentiation; transcription initiation-coupled chromatin remodeling; type B pancreatic cell differentiation; type B pancreatic cell proliferation
Reference #:  O88559 (UniProtKB)
Alt. Names/Synonyms: AW045611; Men1; Menin; multiple endocrine neoplasia 1; OTTMUSP00000020152; OTTMUSP00000020153; OTTMUSP00000020154; OTTMUSP00000029796
Gene Symbols: Men1
Molecular weight: 67,501 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MEN1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene