MEN1 Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component:  chromatin; cleavage furrow; cytoplasm; cytosol; endoplasmic reticulum lumen; histone methyltransferase complex; nuclear chromatin; nuclear chromosome, telomeric region; nuclear matrix; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  double-stranded DNA binding; four-way junction DNA binding; protein binding; protein binding, bridging; protein N-terminus binding; R-SMAD binding; transcription regulatory region DNA binding; Y-form DNA binding
Biological Process:  beta-catenin-TCF complex assembly; brain development; cellular protein metabolic process; cellular response to DNA damage stimulus; cellular response to glucose stimulus; cellular response to peptide hormone stimulus; decidualization; DNA repair; histone lysine methylation; MAPK cascade; mitotic cell cycle; negative regulation of cell cycle; negative regulation of cell cycle G1/S phase transition; negative regulation of cell proliferation; negative regulation of cell-substrate adhesion; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of DNA-binding transcription factor activity; negative regulation of epithelial cell proliferation; negative regulation of JNK cascade; negative regulation of osteoblast differentiation; negative regulation of protein phosphorylation; negative regulation of telomerase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; osteoblast development; positive regulation of protein binding; positive regulation of transcription by RNA polymerase II; positive regulation of transforming growth factor beta receptor signaling pathway; post-translational protein modification; regulation of activin receptor signaling pathway; regulation of type B pancreatic cell proliferation; response to gamma radiation; response to transforming growth factor beta; response to UV; type B pancreatic cell differentiation
Disease: Multiple Endocrine Neoplasia, Type I
Reference #:  O00255 (UniProtKB)
Alt. Names/Synonyms: endocrine adenomatosis, multiple; MEAI; MEN1; Menin; multiple endocrine neoplasia I; SCG2
Gene Symbols: MEN1
Molecular weight: 68,023 Da
Basal Isoelectric point: 6.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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