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PHF2
Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. Widely expressed, including in liver (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: Demethylase; EC 1.14.11.-; Nucleolus |
| Chromosomal Location of mouse Ortholog: 13 A5|13 24.96 cM |
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Cellular Component:
chromosome; chromosome, centromeric region; kinetochore; nucleolus; nucleoplasm; nucleus
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Molecular Function:
dioxygenase activity; histone demethylase activity; histone H3K9 demethylase activity; histone H4K20 demethylase activity; iron ion binding; metal ion binding; methylated histone binding; oxidoreductase activity; protein binding; transcription coactivator activity; transcription coregulator activity; zinc ion binding
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Biological Process:
chromatin organization; negative regulation of rDNA heterochromatin formation; protein demethylation; regulation of transcription by RNA polymerase II; transcription initiation-coupled chromatin remodeling
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Reference #:
Q9WTU0
(UniProtKB)
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Alt. Names/Synonyms: GRC5; Kiaa0662; Lysine-specific demethylase PHF2; PHD finger protein 2; Phf2
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Gene Symbols: Phf2
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Molecular weight:
120,814 Da
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Basal Isoelectric point:
9.25
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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