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ELL
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. Belongs to the ELL/occludin family. Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Oncoprotein; Transcription initiation complex |
| Chromosomal Location of mouse Ortholog: 8|8 B3.3 |
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Cellular Component:
Cajal body; cytosol; euchromatin; histone locus body; nuclear body; nuclear speck; nucleoplasm; nucleus; transcription elongation factor complex
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Molecular Function:
cis-regulatory region sequence-specific DNA binding; phosphatase binding
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Biological Process:
in utero embryonic development; positive regulation of transcription by RNA polymerase III; positive regulation of transcription elongation by RNA polymerase II; snRNA transcription by RNA polymerase II; snRNA transcription by RNA polymerase III; transcription elongation by RNA polymerase II
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Reference #:
O08856
(UniProtKB)
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Alt. Names/Synonyms: Eleven-nineteen lysine-rich leukemia protein; Ell; Ell1; elongation factor RNA polymerase II; Men; RNA polymerase II elongation factor ELL; RNA POLYMERASE II ELONGATION FACTOR ELL (ELEVEN-NINETEEN LYSINE-RICH LEUKEMIA PROTEIN)
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Gene Symbols: Ell
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Molecular weight:
67,146 Da
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Basal Isoelectric point:
9.28
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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