ELL Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. Belongs to the ELL/occludin family. Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Oncoprotein; Transcription initiation complex
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component:  Cajal body; histone locus body; nuclear speck; nucleoplasm; transcription elongation factor complex; transcriptionally active chromatin
Molecular Function:  phosphatase binding; protein binding
Biological Process:  in utero embryonic development; negative regulation of phosphatase activity; positive regulation of DNA-templated transcription, elongation; positive regulation of transcription by RNA polymerase III; positive regulation of transcription elongation from RNA polymerase II promoter; snRNA transcription by RNA polymerase II; snRNA transcription by RNA polymerase III; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter
Reference #:  P55199 (UniProtKB)
Alt. Names/Synonyms: C19orf17; DKFZp434I1916; Eleven-nineteen lysine-rich leukemia protein; ELL; ELL gene (11-19 lysine-rich leukemia gene); ELL1; elongation factor RNA polymerase II; MEN; RNA polymerase II elongation factor ELL
Gene Symbols: ELL
Molecular weight: 68,265 Da
Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ELL

Protein Structure Not Found.


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