G-alpha t1 Functions as signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina. Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase. Belongs to the G-alpha family. G(i/o/t/z) subfamily. Rod photoreceptor cells (PubMed:1614872). Predominantly expressed in the retina followed by the ciliary body, iris and retinal pigment epithelium (PubMed:22190596). Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z))
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component:  apical plasma membrane; cytosol; membrane; neuronal cell body; photoreceptor connecting cilium; photoreceptor disc membrane; photoreceptor inner segment; photoreceptor outer segment; photoreceptor outer segment membrane; plasma membrane
Molecular Function:  acyl binding; GDP binding; GTP binding; GTPase activity; metal ion binding; protein kinase binding
Biological Process:  cell proliferation; cellular response to electrical stimulus; detection of chemical stimulus involved in sensory perception of bitter taste; detection of light stimulus involved in visual perception; eye photoreceptor cell development; negative regulation of cyclic-nucleotide phosphodiesterase activity; phototransduction, visible light; positive regulation of cyclic-nucleotide phosphodiesterase activity; protein folding; regulation of rhodopsin mediated signaling pathway; response to light intensity; response to light stimulus; retina development in camera-type eye; rhodopsin mediated signaling pathway; sensory perception of umami taste; signal transduction; visual perception
Disease: Night Blindness, Congenital Stationary, Autosomal Dominant 3; Night Blindness, Congenital Stationary, Type 1g
Reference #:  P11488 (UniProtKB)
Alt. Names/Synonyms: CSNBAD3; GBT1; GNAT1; GNATR; guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1; Guanine nucleotide-binding protein G(t) subunit alpha-1; guanine nucleotide-binding protein G(T), alpha-1 subunit; rod-type transducin alpha subunit; Transducin alpha-1 chain; transducin, rod-specific
Gene Symbols: GNAT1
Molecular weight: 40,041 Da
Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Phospholipase Signaling  |  PI3K/Akt Signaling
Select Structure to View Below

G-alpha t1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein