RAI14 Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. Highly expressed in placenta, muscle, kidney and testis. Moderately expressed in heart, brain, lung, liver and intestine. Isoform 2 is widely expressed and expressed in fetal and adult testes, and spermatozoa. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 5p13.2
Cellular Component:  anchoring junction; cell cortex; cytoskeleton; cytosol; fibrillar center; nucleoplasm
Molecular Function:  actin binding; protein binding
Biological Process:  cell differentiation; spermatogenesis
Reference #:  Q9P0K7 (UniProtKB)
Alt. Names/Synonyms: Ankycorbin; Ankyrin repeat and coiled-coil structure-containing protein; DKFZp564G013; KIAA1334; NORPEG; Novel retinal pigment epithelial cell protein; RAI13; RAI14; retinoic acid induced 14; Retinoic acid-induced protein 14
Gene Symbols: RAI14
Molecular weight: 110,041 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
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RAI14

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein