RNF138
E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase |
Chromosomal Location of human Ortholog: 18q12.1 |
Cellular Component:
site of double-strand break
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Molecular Function:
metal ion binding; protein binding; protein kinase binding; single-stranded DNA binding; ubiquitin protein ligase activity
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Biological Process:
cellular response to leukemia inhibitory factor; DNA double-strand break processing involved in repair via single-strand annealing; double-strand break repair via homologous recombination; protein ubiquitination; Wnt signaling pathway
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Reference #:
Q8WVD3
(UniProtKB)
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Alt. Names/Synonyms: E3 ubiquitin-protein ligase RNF138; hNARF; HSD-4; MGC8758; NARF; nemo-like kinase associated ring finger protein; Nemo-like kinase-associated RING finger protein; NLK-associated RING finger protein; RING finger protein 138; ring finger protein 138, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF138; RN138; RNF138; STRIN; testicular tissue protein Li 165
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Gene Symbols: RNF138
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Molecular weight:
28,193 Da
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Basal Isoelectric point:
6.5
Predict pI for various phosphorylation states
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