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ZNF16
Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis. Belongs to the krueppel C2H2-type zinc-finger protein family. Ubiquitous. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein |
| Chromosomal Location of human Ortholog: 8q24.3 |
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Cellular Component:
nucleolus; nucleoplasm; nucleus
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Molecular Function:
DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding
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Biological Process:
cell cycle; cell division; cellular response to sodium dodecyl sulfate; negative regulation of apoptotic process; positive regulation of cell cycle phase transition; positive regulation of cell division; positive regulation of cell population proliferation; positive regulation of erythrocyte differentiation; positive regulation of kinase activity; positive regulation of megakaryocyte differentiation; regulation of transcription by RNA polymerase II
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Reference #:
P17020
(UniProtKB)
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Alt. Names/Synonyms: DKFZp547L155; HZF1; KOX9; Putative uncharacterized protein DKFZp547L155; Zinc finger protein 16; zinc finger protein KOX9; zinc finger protein Kruppel type 9; ZNF16
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Gene Symbols: ZNF16
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Molecular weight:
76,472 Da
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Basal Isoelectric point:
8.31
Predict pI for various phosphorylation states
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