ZNF16 Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis. Belongs to the krueppel C2H2-type zinc-finger protein family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein
Chromosomal Location of human Ortholog: 8q24.3
Cellular Component:  nucleolus; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; protein binding
Biological Process:  cell cycle; cell division; cellular response to sodium dodecyl sulfate; negative regulation of apoptotic process; positive regulation of cell cycle phase transition; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of erythrocyte differentiation; positive regulation of kinase activity; positive regulation of megakaryocyte differentiation; regulation of transcription by RNA polymerase II
Reference #:  P17020 (UniProtKB)
Alt. Names/Synonyms: DKFZp547L155; HZF1; KOX9; Putative uncharacterized protein DKFZp547L155; Zinc finger protein 16; zinc finger protein KOX9; zinc finger protein Kruppel type 9; ZNF16
Gene Symbols: ZNF16
Molecular weight: 76,472 Da
Basal Isoelectric point: 8.31  Predict pI for various phosphorylation states
Select Structure to View Below

ZNF16

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein