CROP Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. Belongs to the Luc7 family. Widely expressed. Highest levels in heart, brain, pancreas, thymus, ovary, small intestine and peripheral blood leukocytes, as well as cerebellum, putamen and pituitary gland. Lowest levels in lung, liver and kidney. Also expressed in fetal tissues, including brain, heart, kidney, thymus and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component:  nuclear speck; nucleoplasm; nucleus
Molecular Function:  DNA binding; mRNA binding; protein binding
Biological Process:  RNA splicing
Reference #:  O95232 (UniProtKB)
Alt. Names/Synonyms: cAMP regulatory element-associated protein 1; cisplatin resistance associated overexpressed protein; cisplatin resistance-associated overexpressed protein; Cisplatin resistance-associated-overexpressed protein; CRA; CRE-associated protein 1; CREAP-1; CREAP1; CROP; hLuc7A; LC7L3; LUC7 like 3 pre-mRNA splicing factor; LUC7-like 3; LUC7-like 3 (S. cerevisiae); Luc7-like protein 3; Luc7A; LUC7L3; O48; OA48-18; Okadaic acid-inducible phosphoprotein OA48-18
Gene Symbols: LUC7L3
Molecular weight: 51,466 Da
Basal Isoelectric point: 9.81  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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