FANCI Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; DNA repair, damage
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  DNA binding; DNA polymerase binding; protein binding
Biological Process:  cell cycle; interstrand cross-link repair; positive regulation of protein ubiquitination
Disease: Fanconi Anemia, Complementation Group I
Reference #:  Q9NVI1 (UniProtKB)
Alt. Names/Synonyms: FA complementation group I; FANCI; Fanconi anemia complementation group I; Fanconi anemia group I protein; Fanconi anemia, complementation group I; FLJ10719; KIAA1794; Protein FACI
Gene Symbols: FANCI
Molecular weight: 149,324 Da
Basal Isoelectric point: 6.31  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein