SPG21 May play a role as a negative regulatory factor in CD4-dependent T-cell activation. Belongs to the AB hydrolase superfamily. Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in J.CaM1.6, HuT 78 and HeLa cell lines (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of human Ortholog: 15q22.31
Cellular Component:  cytosol; endosome membrane; Golgi apparatus; intracellular membrane-bounded organelle; trans-Golgi network transport vesicle
Molecular Function:  CD4 receptor binding; protein binding
Biological Process:  antigen receptor-mediated signaling pathway
Disease: Mast Syndrome
Reference #:  Q9NZD8 (UniProtKB)
Alt. Names/Synonyms: ABHD21; Acid cluster protein 33; ACP33; BM-019; GL010; Maspardin; MAST; spastic paraplegia 21; spastic paraplegia 21 (autosomal recessive, Mast syndrome); Spastic paraplegia 21 autosomal recessive Mast syndrome protein; Spastic paraplegia 21 protein; SPG21; SPG21 abhydrolase domain containing, maspardin; SPG21, maspardin
Gene Symbols: SPG21
Molecular weight: 34,960 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein