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RIC8A
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. Belongs to the synembryn family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GEF; GEF, misc. |
| Chromosomal Location of human Ortholog: 11p15.5 |
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Cellular Component:
cytoplasm; plasma membrane
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Molecular Function:
G-protein alpha-subunit binding; guanyl-nucleotide exchange factor activity; protein binding
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Biological Process:
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; basement membrane organization; cell migration involved in gastrulation; cell-cell adhesion involved in gastrulation; G protein-coupled receptor signaling pathway; in utero embryonic development; vasculature development; visual learning
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Reference #:
Q9NPQ8
(UniProtKB)
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Alt. Names/Synonyms: MGC104517; MGC131931; MGC148073; MGC148074; Protein Ric-8A; resistance to inhibitors of cholinesterase 8 homolog A; resistance to inhibitors of cholinesterase 8 homolog A (C. elegans); RIC8; RIC8 guanine nucleotide exchange factor A; RIC8A; synembryn; Synembryn-A
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Gene Symbols: RIC8A
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Molecular weight:
59,710 Da
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Basal Isoelectric point:
5.2
Predict pI for various phosphorylation states
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