NEXN Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. Abundantly expressed in heart and skeletal muscle, and at lower levels in placenta, lung, liver and pancreas. Also expressed in HeLaS3 and MOLT-4 cell lines. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p31.1
Cellular Component:  cytoskeleton; Z disc
Molecular Function:  actin filament binding; structural constituent of muscle
Biological Process:  regulation of cell migration; regulation of cytoskeleton organization; response to bacterium
Disease: Cardiomyopathy, Dilated, 1cc; Cardiomyopathy, Familial Hypertrophic, 20
Reference #:  Q0ZGT2 (UniProtKB)
Alt. Names/Synonyms: F-actin-binding protein; MGC104234; MGC138865; MGC138866; Nelin; Nexilin; nexilin (F actin binding protein); NEXN
Gene Symbols: NEXN
Molecular weight: 80,658 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein