PRUNE Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization. Belongs to the PPase class C family. Prune subfamily. Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Nucleotide Metabolism - purine
Chromosomal Location of human Ortholog: 1q21.3
Cellular Component:  cytoplasm; cytosol; focal adhesion; nucleus
Molecular Function:  exopolyphosphatase activity; inorganic diphosphate phosphatase activity; metal ion binding; phosphatase activity; protein binding; tubulin binding
Biological Process:  regulation of microtubule polymerization; regulation of neurogenesis
Disease: Neurodevelopmental Disorder With Microcephaly, Hypotonia, And Variable Brain Anomalies
Reference #:  Q86TP1 (UniProtKB)
Alt. Names/Synonyms: DRES-17; DRES17; Drosophila-related expressed sequence 17; Exopolyphosphatase PRUNE1; H-PRUNE; hPrune; HTcD37; HTCD37; NMIHBA; Protein prune homolog; Protein prune homolog 1; PRUN1; PRUNE; prune exopolyphosphatase; prune exopolyphosphatase 1; PRUNE1
Gene Symbols: PRUNE1
Molecular weight: 50,200 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene