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PRUNE
Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization. Belongs to the PPase class C family. Prune subfamily. Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.1.1; Hydrolase; Nucleotide Metabolism - purine |
| Chromosomal Location of human Ortholog: 1q21.3 |
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Cellular Component:
cytoplasm; cytosol; focal adhesion; nucleus
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Molecular Function:
exopolyphosphatase activity; inorganic diphosphate phosphatase activity; metal ion binding; phosphatase activity; protein binding; tubulin binding
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Biological Process:
regulation of microtubule polymerization; regulation of neurogenesis
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Disease: Neurodevelopmental Disorder With Microcephaly, Hypotonia, And Variable Brain Anomalies
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Reference #:
Q86TP1
(UniProtKB)
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Alt. Names/Synonyms: DRES-17; DRES17; Drosophila-related expressed sequence 17; Exopolyphosphatase PRUNE1; H-PRUNE; hPrune; HTcD37; HTCD37; NMIHBA; Protein prune homolog; Protein prune homolog 1; PRUN1; PRUNE; prune exopolyphosphatase; prune exopolyphosphatase 1; PRUNE1
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Gene Symbols: PRUNE1
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Molecular weight:
50,200 Da
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Basal Isoelectric point:
5.28
Predict pI for various phosphorylation states
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