STAM1 iso2 Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. Belongs to the STAM family. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component:  cytosol; early endosome membrane; ESCRT-0 complex
Molecular Function:  protein binding; SH3/SH2 adaptor activity; ubiquitin-like protein ligase binding
Biological Process:  endosomal transport; intracellular protein transport; macroautophagy; membrane organization; multivesicular body assembly; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of exosomal secretion; positive regulation of signal transduction; protein deubiquitination; regulation of extracellular exosome assembly; signal transduction
Reference #:  Q92783-2 (UniProtKB)
Alt. Names/Synonyms: HSE1 homolog; Signal transducing adapter molecule 1; signal transducing adaptor molecule; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; STAM; STAM-1; STAM1; STAM1 iso2
Gene Symbols: STAM
Molecular weight: 44,972 Da
Basal Isoelectric point: 4.75  Predict pI for various phosphorylation states
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STAM1 iso2

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene