KIF23 iso3 Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor
Cellular Component:  centralspindlin complex; centrosome; cytosol; Flemming body; intercellular bridge; midbody; mitotic spindle; nucleoplasm; nucleus; spindle
Molecular Function:  ATP binding; microtubule binding; protein binding
Biological Process:  actomyosin contractile ring assembly; antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule-based movement; mitotic cytokinesis; mitotic spindle elongation; mitotic spindle midzone assembly; plus-end-directed vesicle transport along microtubule; positive regulation of cytokinesis; retrograde vesicle-mediated transport, Golgi to ER
Reference #:  Q02241-3 (UniProtKB)
Alt. Names/Synonyms: CHO1; KIF23; kinesin family member 23; kinesin-like 5 (mitotic kinesin-like protein 1); Kinesin-like protein 5; Kinesin-like protein KIF23; KNSL5; mitotic kinesin-like 1; Mitotic kinesin-like protein 1; MKLP-1; MKLP1
Gene Symbols: KIF23
Molecular weight: 77,699 Da
Basal Isoelectric point: 8.14  Predict pI for various phosphorylation states
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KIF23 iso3

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene