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SGOL2
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. Belongs to the shugoshin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of human Ortholog: 2q33.1 |
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Cellular Component:
chromosome, centromeric region; cytosol; kinetochore; mitotic cohesin complex; nuclear body; nucleoplasm
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Molecular Function:
protein binding
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Biological Process:
cell division; chromosome segregation; meiotic cell cycle; meiotic sister chromatid cohesion
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Reference #:
Q562F6
(UniProtKB)
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Alt. Names/Synonyms: FLJ25211; MGC129665; Sgo2; SGOL2; Shugoshin 2; Shugoshin-2; Shugoshin-like 2; shugoshin-like 2 (S. pombe); Tripin
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Gene Symbols: SGO2
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Molecular weight:
144,739 Da
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Basal Isoelectric point:
8.09
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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