SGOL2 Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Belongs to the shugoshin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 2q33.1
Cellular Component:  chromosome, centromeric region; condensed chromosome kinetochore; cytosol; mitotic cohesin complex; nuclear body; nucleoplasm
Molecular Function:  protein binding
Biological Process:  cell division; meiotic sister chromatid cohesion, centromeric
Reference #:  Q562F6 (UniProtKB)
Alt. Names/Synonyms: FLJ25211; MGC129665; Sgo2; SGOL2; Shugoshin 2; Shugoshin-2; Shugoshin-like 2; shugoshin-like 2 (S. pombe); Tripin
Gene Symbols: SGO2
Molecular weight: 144,739 Da
Basal Isoelectric point: 8.09  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein