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MON1A
Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. Belongs to the MON1/SAND family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of Human Ortholog: 3p21.31 |
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Cellular Component:
cytosol; Mon1-Ccz1 complex
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Molecular Function:
guanyl-nucleotide exchange factor activity; protein binding
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Reference #:
Q86VX9
(UniProtKB)
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Alt. Names/Synonyms: FLJ97088; MGC13272; MON1 homolog A (yeast); MON1 homolog A, secretory trafficking associated; MON1 secretory trafficking family member A; MON1A; SAND1; Vacuolar fusion protein MON1 homolog A
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Gene Symbols: MON1A
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Molecular weight:
62,131 Da
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Basal Isoelectric point:
5.9
Predict pI for various phosphorylation states
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