Ezrin Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 6q25.3
Cellular Component:  actin cytoskeleton; actin filament; apical part of cell; apical plasma membrane; astrocyte projection; basolateral plasma membrane; brush border; cell body; cell periphery; cell projection; cell tip; ciliary basal body; cortical cytoskeleton; cytoplasm; cytoplasmic side of apical plasma membrane; cytosol; endosome; extrinsic component of membrane; fibrillar center; filopodium; immunological synapse; invadopodium; microspike; microvillus; microvillus membrane; perinuclear region of cytoplasm; plasma membrane; plasma membrane raft; protein-containing complex; ruffle; ruffle membrane; Schwann cell microvillus; T-tubule; uropod
Molecular Function:  actin binding; actin filament binding; ATPase binding; cell adhesion molecule binding; disordered domain specific binding; identical protein binding; microtubule binding; protein binding; protein C-terminus binding; protein domain specific binding; protein kinase A binding; protein kinase A catalytic subunit binding; protein kinase A regulatory subunit binding; S100 protein binding
Biological Process:  actin cytoskeleton reorganization; actin filament bundle assembly; astral microtubule organization; axon guidance; cellular protein-containing complex localization; cellular response to cAMP; cortical microtubule organization; cytoskeletal anchoring at plasma membrane; establishment of centrosome localization; establishment of endothelial barrier; filopodium assembly; intestinal D-glucose absorption; leukocyte cell-cell adhesion; membrane to membrane docking; microvillus assembly; negative regulation of ERK1 and ERK2 cascade; negative regulation of interleukin-2 secretion; negative regulation of p38MAPK cascade; negative regulation of T cell receptor signaling pathway; negative regulation of transcription by RNA polymerase II; phosphatidylinositol-mediated signaling; positive regulation of cellular protein catabolic process; positive regulation of early endosome to late endosome transport; positive regulation of gene expression; positive regulation of multicellular organism growth; positive regulation of protein localization to early endosome; positive regulation of protein localization to plasma membrane; positive regulation of protein secretion; protein kinase A signaling; protein localization to cell cortex; protein localization to plasma membrane; receptor internalization; regulation of cell shape; regulation of microvillus length; regulation of organelle assembly; sphingosine-1-phosphate receptor signaling pathway; terminal web assembly
Reference #:  P15311 (UniProtKB)
Alt. Names/Synonyms: CVIL; CVL; Cytovillin; cytovillin 2; DKFZp762H157; epididymis secretory protein Li 105; EZR; EZRI; Ezrin; FLJ26216; HEL-S-105; MGC1584; p81; VIL2; villin 2 (ezrin); Villin-2
Gene Symbols: EZR
Molecular weight: 69,413 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein