RNF157 E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons. Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical. May act as a scaffold molecule to regulate this process. Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of human Ortholog: 17q25.1
Cellular Component:  cell body; cytoplasm
Molecular Function:  metal ion binding; ubiquitin protein ligase activity
Biological Process:  negative regulation of apoptotic process; positive regulation of dendrite extension; protein autoubiquitination; protein ubiquitination
Reference #:  Q96PX1 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin ligase RNF157; KIAA1917; RING finger protein 157; RING-type E3 ubiquitin transferase RNF157; RN157; RNF157
Gene Symbols: RNF157
Molecular weight: 73,579 Da
Basal Isoelectric point: 4.61  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene