SHOX Controls fundamental aspects of growth and development. Belongs to the paired homeobox family. Bicoid subfamily. SHOXA is expressed in skeletal muscle, placenta, pancreas, heart and bone marrow fibroblast and SHOXB is highly expressed in bone marrow fibroblast followed by kidney and skeletal muscle. SHOXB is not expressed in brain, kidney, liver and lung. Highly expressed in osteogenic cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: Xp22.33 and Yp11.2
Cellular Component:  intracellular membrane-bounded organelle; nucleoplasm
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; sequence-specific DNA binding
Biological Process:  positive regulation of transcription by RNA polymerase II; skeletal system development; transcription by RNA polymerase II
Disease: Langer Mesomelic Dysplasia; Leri-weill Dyschondrosteosis; Short Stature, Idiopathic, X-linked
Reference #:  O15266 (UniProtKB)
Alt. Names/Synonyms: GCFX; growth control factor, X-linked; PHOG; Pseudoautosomal homeobox-containing osteogenic protein; short stature homeobox; Short stature homeobox protein; Short stature homeobox-containing protein; SHOX; SHOXY; SS
Gene Symbols: SHOX
Molecular weight: 32,236 Da
Basal Isoelectric point: 7.23  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein