ERF Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment. May be important for regulating trophoblast stem cell differentiation. Belongs to the ETS family. Highest levels in testis, ovary, pancreas, and heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 19q13.2
Cellular Component:  chromatin; cytosol; nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; sequence-specific DNA binding
Biological Process:  cell differentiation; negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II
Disease: Chitayat Syndrome; Craniosynostosis 4
Reference #:  P50548 (UniProtKB)
Alt. Names/Synonyms: CHYTS; CRS4; ERF; ETS domain-containing transcription factor ERF; Ets2 repressor factor; PE-2; PE2
Gene Symbols: ERF
Molecular weight: 58,703 Da
Basal Isoelectric point: 6.85  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein