ERF
Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment. May be important for regulating trophoblast stem cell differentiation. Belongs to the ETS family. Highest levels in testis, ovary, pancreas, and heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: DNA-binding; Transcription factor |
Chromosomal Location of human Ortholog: 19q13.2 |
Cellular Component:
chromatin; cytosol; nucleoplasm; nucleus
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Molecular Function:
DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; sequence-specific DNA binding
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Biological Process:
cell differentiation; negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II
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Disease: Chitayat Syndrome; Craniosynostosis 4
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Reference #:
P50548
(UniProtKB)
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Alt. Names/Synonyms: CHYTS; CRS4; ERF; ETS domain-containing transcription factor ERF; Ets2 repressor factor; PE-2; PE2
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Gene Symbols: ERF
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Molecular weight:
58,703 Da
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Basal Isoelectric point:
6.85
Predict pI for various phosphorylation states
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