GLI1 Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation. Interacts with KIF7. Interacts with ZIC1; the interaction enhances transcription activation. Amplified in glioblastoma cells. Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract. Belongs to the GLI C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 10 D3|10 74.5 cM
Cellular Component:  axoneme; cilium; cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; microtubule binding; nucleic acid binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription regulatory region DNA binding
Biological Process:  canonical Wnt signaling pathway; cell differentiation; cerebellar cortex morphogenesis; dorsal/ventral pattern formation; epidermal cell differentiation; liver regeneration; lung development; multicellular organism development; negative regulation of canonical Wnt signaling pathway; notochord regression; osteoblast differentiation; pituitary gland development; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle G1/S phase transition; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of smoothened signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; proximal/distal pattern formation; regulation of hepatocyte proliferation; regulation of osteoblast differentiation; response to wounding; signal transduction; smoothened signaling pathway; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation; spermatogenesis; ventral midline development
Reference #:  P47806 (UniProtKB)
Alt. Names/Synonyms: AV235269; Gli; GLI-Kruppel family member GLI1; Gli1; Glioma-associated oncogene homolog; Zfp-5; Zfp5; zinc finger protein 5; Zinc finger protein GLI1
Gene Symbols: Gli1
Molecular weight: 118,560 Da
Basal Isoelectric point: 7.14  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene