GLI1 Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling. Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. Belongs to the GLI C2H2-type zinc-finger protein family. Detected in testis (at protein level) (PubMed:2105456). Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract (PubMed:19878745). Isoform 1 is detected in brain, spleen, pancreas, liver, kidney and placenta; isoform 2 is not detectable in these tissues (PubMed:19706761). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Oncoprotein; Transcription factor
Chromosomal Location of mouse Ortholog: 10 D3|10 74.5 cM
Cellular Component:  axoneme; cilium; cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; microtubule binding; nucleic acid binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription regulatory region DNA binding
Biological Process:  canonical Wnt signaling pathway; cell differentiation; cerebellar cortex morphogenesis; dorsal/ventral pattern formation; epidermal cell differentiation; liver regeneration; lung development; multicellular organism development; negative regulation of canonical Wnt signaling pathway; notochord regression; osteoblast differentiation; pituitary gland development; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle G1/S phase transition; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of smoothened signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; proximal/distal pattern formation; regulation of hepatocyte proliferation; regulation of osteoblast differentiation; response to wounding; signal transduction; smoothened signaling pathway; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation; spermatogenesis; ventral midline development
Reference #:  P47806 (UniProtKB)
Alt. Names/Synonyms: AV235269; Gli; GLI-Kruppel family member GLI1; Gli1; Glioma-associated oncogene homolog; Zfp; Zfp-; Zfp-5; Zfp5; zinc finger protein 5; Zinc finger protein GLI1
Gene Symbols: Gli1
Molecular weight: 118,560 Da
Basal Isoelectric point: 7.14  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene