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14-3-3 epsilon
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm. Belongs to the 14-3-3 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of mouse Ortholog: 11 B5|11 45.92 cM |
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Cellular Component:
axon; central region of growth cone; cytoplasm; cytosol; glutamatergic synapse; kinesin complex; nucleus; plasma membrane; synapse
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Molecular Function:
calcium channel regulator activity; enzyme binding; histone deacetylase binding; identical protein binding; phosphoprotein binding; phosphoserine residue binding; potassium channel regulator activity; protein binding; protein domain specific binding; protein heterodimerization activity; protein phosphatase binding; protein-containing complex binding; scaffold protein binding; transmembrane transporter binding; ubiquitin protein ligase binding
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Biological Process:
cellular response to heat; cerebral cortex development; hippocampus development; MAPK cascade; negative regulation of calcium ion export across plasma membrane; negative regulation of calcium ion transmembrane transporter activity; negative regulation of peptidyl-serine dephosphorylation; negative regulation of protein dephosphorylation; neuron migration; positive regulation of protein export from nucleus; protein localization to nucleus; protein targeting; regulation of cytosolic calcium ion concentration; regulation of membrane repolarization; regulation of mitotic cell cycle; regulation of postsynaptic membrane neurotransmitter receptor levels; regulation of potassium ion transmembrane transporter activity; signal transduction
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Reference #:
P62259
(UniProtKB)
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Alt. Names/Synonyms: 14-3-3 epsilon; 14-3-3 protein epsilon; 14-3-3E; 1433E; AU019196; OTTMUSP00000006521; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide; Ywhae
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Gene Symbols: Ywhae
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Molecular weight:
29,174 Da
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Basal Isoelectric point:
4.63
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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G2/M DNA Damage Checkpoint
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Growth And Differentiation Control by MAPKs
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Hippo Signaling
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Mitochondrial Control of Apoptosis
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PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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