GCAP2 Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure. Defects in GUCA1B are the cause of retinitis pigmentosa type 48 (RP48). RP48 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding
Chromosomal Location of Human Ortholog: 17|17 C
Cellular Component:  membrane; photoreceptor inner segment; photoreceptor outer segment; plasma membrane
Molecular Function:  calcium ion binding; calcium sensitive guanylate cyclase activator activity; guanylate cyclase regulator activity; metal ion binding
Biological Process:  phototransduction; regulation of guanylate cyclase activity; response to stimulus; visual perception
Reference #:  Q8VBV8 (UniProtKB)
Alt. Names/Synonyms: BC018258; GCAP 2; GCAP2; GCAP2 (retina); Guanylate cyclase activator 1B; Guanylyl cyclase-activating protein 2; GUC1B; Guca1b; MGC36472
Gene Symbols: Guca1b
Molecular weight: 23,520 Da
Basal Isoelectric point: 4.92  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene