AurA Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. Note: This description may include information from UniProtKB.
Protein type: AUR family; EC; Kinase, protein; Oncoprotein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Cellular Component:  centrosome; cytoplasm; cytoskeleton; microtubule; microtubule organizing center; spindle; spindle microtubule; spindle pole
Molecular Function:  ATP binding; kinase activity; kinesin binding; microtubule binding; nucleotide binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell cycle; cell division; centrosome cycle; meiotic cell cycle; meiotic spindle organization; microtubule cytoskeleton organization; mitotic cell cycle; mitotic centrosome separation; mitotic spindle assembly; mitotic spindle organization; peptidyl-serine phosphorylation; phosphorylation; protein autophosphorylation; protein phosphorylation
Reference #:  Q91820 (UniProtKB)
Alt. Names/Synonyms: aik; ARK-1; aur-a; aura; aurka-a; Aurora kinase A-A; aurora2; btak; Eg2; p46Eg265; pEg2; stk15; STK6; stk7
Gene Symbols: aurka
Molecular weight: 46,372 Da
Basal Isoelectric point: 9.49  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
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Cross-references to other databases:  AlphaFold  |  STRING  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene