TPX2 a microtubule-associated protein required for meiotic and mitotic spindle assembly. Targets a plus end-directed motor (XKLP2) to the minus ends of microtubules in the mitotic spindle. Required for microtubule nucleation around chromosomes in response to the local generation of RanGTP. Binds to and activates Aurora A kinase and targets it to the mitotic spindle.
Protein type: Cell cycle regulation; Microtubule-binding
Cellular Component: 
Reference #:  Q6NUF4 (UniProtKB)
Alt. Names/Synonyms: dil-2; hctp4; repp86; Targeting protein for Xklp2-A; TPX2, microtubule-associated L homeolog; tpx2-a; tpx2-b; TPX2A
Gene Symbols: tpx2.L
Molecular weight: 82,512 Da
Basal Isoelectric point: 9.44  Predict pI for various phosphorylation states
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TPX2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept