NHE3 Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 13 C1|13 40.15 cM
Cellular Component:  apical plasma membrane; brush border; brush border membrane; extracellular exosome; integral component of membrane; membrane; plasma membrane; vesicle
Molecular Function:  antiporter activity; PDZ domain binding; potassium:proton antiporter activity; sodium:proton antiporter activity; solute:proton antiporter activity
Biological Process:  cation transport; ion transport; potassium ion transmembrane transport; receptor-mediated endocytosis; regulation of intracellular pH; regulation of pH; regulation of sodium ion transport; sodium ion import across plasma membrane; sodium ion transport; transmembrane transport
Reference #:  G3X939 (UniProtKB)
Alt. Names/Synonyms: 9030624O13Rik; AI930210; Na+/H+ exchanger; NHE; NHE-; NHE-3; NHE3; SL9A3; Slc9a3; Sodium/hydrogen exchanger 3; solute carrier family 9 (sodium/hydrogen exchanger), member 3
Gene Symbols: Slc9a3
Molecular weight: 93,104 Da
Basal Isoelectric point: 7.36  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein