ER-beta a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 14q23.2-q23.3
Cellular Component:  mitochondrion; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; estrogen receptor activity; estrogen response element binding; identical protein binding; nuclear receptor activity; protein binding; receptor antagonist activity; RNA polymerase II proximal promoter sequence-specific DNA binding; steroid binding; steroid hormone receptor activity; transcription coactivator activity; zinc ion binding
Biological Process:  cell-cell signaling; intracellular estrogen receptor signaling pathway; negative regulation of cell growth; negative regulation of signaling receptor activity; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-binding transcription factor activity; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; signal transduction; transcription initiation from RNA polymerase II promoter
Disease: Ovarian Dysgenesis 8
Reference #:  Q92731 (UniProtKB)
Alt. Names/Synonyms: ER-beta; Erb; ESR-BETA; ESR2; ESRB; ESTRB; estrogen receptor 2 (ER beta); Estrogen receptor beta; estrogen receptor beta 4; NR3A2; Nuclear receptor subfamily 3 group A member 2
Gene Symbols: ESR2
Molecular weight: 59,216 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Select Structure to View Below


Protein Structure Not Found.

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