STAM1 Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. Belongs to the STAM family. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2|2 A1-A2
Cellular Component:  cytoplasm; endosome; ESCRT-0 complex; membrane
Molecular Function:  protein binding; ubiquitin-like protein ligase binding
Biological Process:  intracellular protein transport; positive regulation of exosomal secretion; protein transport; regulation of extracellular exosome assembly
Reference #:  P70297 (UniProtKB)
Alt. Names/Synonyms: OTTMUSP00000012191; Signal transducing adapter molecule 1; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; Stam; STAM-1; Stam1
Gene Symbols: Stam
Molecular weight: 59,771 Da
Basal Isoelectric point: 4.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene