endophilin A1 Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Belongs to the endophilin family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, peripheral; Vesicle
Chromosomal Location of Human Ortholog: 4 C4|4 40.23 cM
Cellular Component:  basal dendrite; cytoplasm; cytosol; early endosome; endosome; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; membrane; neuronal cell body; perinuclear region of cytoplasm; photoreceptor ribbon synapse; presynapse; presynaptic cytosol; Schaffer collateral - CA1 synapse; synapse; synaptic vesicle membrane
Molecular Function:  identical protein binding; lipid binding; protein binding; protein C-terminus binding; protein homodimerization activity; protein kinase binding
Biological Process:  cellular response to brain-derived neurotrophic factor stimulus; dendrite extension; endocytosis; lipid tube assembly; membrane bending; membrane tubulation; neuron projection development; positive regulation of membrane tubulation; regulation of clathrin-dependent endocytosis; regulation of receptor internalization; synaptic vesicle endocytosis; synaptic vesicle uncoating; vesicle scission
Reference #:  Q62420 (UniProtKB)
Alt. Names/Synonyms: 9530001L19Rik; AI120490; AW555077; B930049H17Rik; EEN-B1; endophilin A1; endophilin I; Endophilin-1; Endophilin-A1; OTTMUSP00000008291; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2; SH3-domain GRB2-like 2; Sh3d2a; SH3G2; Sh3gl2; SH3p4; SH3PA
Gene Symbols: Sh3gl2
Molecular weight: 39,955 Da
Basal Isoelectric point: 5.26  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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endophilin A1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene