endophilin A1 Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. Belongs to the endophilin family. Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, peripheral; Vesicle
Chromosomal Location of Human Ortholog: 9p22.2
Cellular Component:  basal dendrite; clathrin-coated endocytic vesicle membrane; cytosol; early endosome; glutamatergic synapse; Golgi membrane; hippocampal mossy fiber to CA3 synapse; neuronal cell body; perinuclear region of cytoplasm; photoreceptor ribbon synapse; plasma membrane; presynaptic cytosol; Schaffer collateral - CA1 synapse; synaptic vesicle membrane
Molecular Function:  identical protein binding; lipid binding; protein binding; protein C-terminus binding; protein homodimerization activity; protein kinase binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; cellular response to brain-derived neurotrophic factor stimulus; central nervous system development; dendrite extension; lipid tube assembly; membrane bending; membrane organization; membrane tubulation; negative regulation of epidermal growth factor receptor signaling pathway; neuron projection development; positive regulation of membrane tubulation; regulation of clathrin-dependent endocytosis; regulation of receptor internalization; signal transduction; synaptic vesicle uncoating; vesicle scission
Reference #:  Q99962 (UniProtKB)
Alt. Names/Synonyms: bA335L15.1 (SH3-domain GRB2-like 2); CNSA2; EEN-B1; endophilin A1; Endophilin A1 BAR domain; Endophilin-1; Endophilin-A1; FLJ20276; FLJ25015; SH3 domain containing GRB2 like 2, endophilin A1; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2; SH3-domain GRB2-like 2; SH3D2A; SH3G2; SH3GL2; SH3P4
Gene Symbols: SH3GL2
Molecular weight: 39,962 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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endophilin A1

Protein Structure Not Found.


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