ER-alpha a widely expressed.nuclear estrogen receptor and transcription factor. Regulates eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Belongs to the nuclear hormone receptor family, NR3 subfamily. Four human isoforms, two each from alternative promoters and alternative splicing have been reported. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1. Isoform 3 is not expressed in the pituitary gland. Isoform 3 is not expressed in the pituitary gland. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of Human Ortholog: 6q25.1-q25.2
Cellular Component:  cytoplasm; cytosol; Golgi apparatus; integral component of membrane; membrane; nuclear chromatin; nucleoplasm; nucleus; plasma membrane; protein-containing complex; transcriptional preinitiation complex; transcriptionally active chromatin
Molecular Function:  ATPase binding; beta-catenin binding; chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; estrogen receptor activity; estrogen receptor binding; estrogen response element binding; identical protein binding; nitric-oxide synthase regulator activity; nuclear receptor activity; protein binding; protein kinase binding; RNA polymerase II proximal promoter sequence-specific DNA binding; steroid binding; TBP-class protein binding; TFIIB-class transcription factor binding; transcription coactivator binding; transcription factor binding; zinc ion binding
Biological Process:  androgen metabolic process; antral ovarian follicle growth; cellular response to estradiol stimulus; cellular response to estrogen stimulus; chromatin remodeling; epithelial cell development; epithelial cell proliferation involved in mammary gland duct elongation; intracellular estrogen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; male gonad development; mammary gland alveolus development; mammary gland branching involved in pregnancy; negative regulation of DNA-binding transcription factor activity; negative regulation of gene expression; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of production of miRNAs involved in gene silencing by miRNA; negative regulation of transcription by RNA polymerase II; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; positive regulation of DNA-binding transcription factor activity; positive regulation of fibroblast proliferation; positive regulation of phospholipase C activity; positive regulation of protein kinase B signaling; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; prostate epithelial cord elongation; protein deubiquitination; protein localization to chromatin; regulation of apoptotic process; regulation of branching involved in prostate gland morphogenesis; regulation of inflammatory response; regulation of intracellular estrogen receptor signaling pathway; regulation of toll-like receptor signaling pathway; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; regulation of Wnt signaling pathway; response to estradiol; response to estrogen; signal transduction; stem cell differentiation; transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter; transcription, DNA-templated; uterus development; vagina development
Disease: Breast Cancer; Estrogen Resistance; Migraine With Or Without Aura, Susceptibility To, 1; Myocardial Infarction, Susceptibility To
Reference #:  P03372 (UniProtKB)
Alt. Names/Synonyms: DKFZp686N23123; E2 receptor alpha; ER; ER-alpha; Era; ESR; ESR1; ESRA; Estradiol receptor; estrogen nuclear receptor alpha; Estrogen receptor; estrogen receptor 1; estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform; estrogen receptor alpha delta 4 +49 isoform; estrogen receptor alpha delta 4*,5,6,7*/654 isoform; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; ESTRR; NR3A1; Nuclear receptor subfamily 3 group A member 1; oestrogen receptor alpha
Gene Symbols: ESR1
Molecular weight: 66,216 Da
Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ER-alpha

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB
1A52
1AKF
1ERE
1ERR
1G50
1GWQ
1GWR
1HCP
1HCQ
1L2I
1PCG
1QKT
1QKU
1R5K
1SJ0
1UOM
1X7E
1X7R
1XP1
1XP6
1XP9
1XPC
1XQC
1YIM
1YIN
1ZKY
2AYR
2B1V
2B1Z
2B23
2BJ4
2FAI
2G44
2G5O
2I0J
2IOG
2IOK
2JF9
2JFA
2LLO
2LLQ
2OCF
2OUZ
2P15
2POG
2Q6J
2Q70
2QA6
2QA8
2QAB
2QE4
2QGT
2QGW
2QH6
2QR9
2QSE
2QXM
2QXS
2QZO
2R6W
2R6Y
2YAT
2YJA
3CBM
3CBO
3CBP
3DT3
3ERD
3ERT
3HLV
3HM1
3L03
3OS8
3OS9
3OSA
3Q95
3Q97
3UU7
3UUA
3UUC
3UUD
4AA6
4DMA
4IU7
4IUI
4IV2
4IV4
4IVW
4IVY
4IW6
4IW8
4IWC
4IWF
4JC3
4JDD
4MG5
4MG6
4MG7
4MG8
4MG9
4MGA
4MGB
4MGC
4MGD
4O6F
4PP6
4PPP
4PPS
4PXM
4Q13
4Q50
4TUZ
4TV1
4XI3
4ZN7
4ZN9
4ZNH
4ZNS
4ZNT
4ZNU
4ZNV
4ZNW
4ZUB
4ZUC
4ZWH
4ZWK
5AAU
5AAV
5ACC
5AK2
5BNU
5BP6
5BPR
5BQ4
5DI7
5DID
5DIE
5DIG
5DK9
5DKB
5DKE
5DKG
5DKS
5DL4
5DLR
5DMC
5DMF
5DP0
5DRJ
5DRM
5DTV
5DU5
5DUE
5DUG
5DUH
5DVS
5DVV
5DWE
5DWG
5DWI
5DWJ
5DX3
5DXB
5DXE
5DXG
5DXK
5DXM
5DXP
5DXQ
5DXR
5DY8
5DYB
5DYD
5DZ0
5DZ1
5DZ3
5DZH
5DZI
5E0W
5E0X
5E14
5E15
5E19
5E1C
5EGV
5EHJ
5EI1
5EIT
5FQP
5FQR
5FQS
5FQT
5FQV
5GS4
5GTR
5HYR
5JMM
5KCC
5KCD
5KCE
5KCF
5KCT
5KCU
5KCW
5KD9
5KR9
5KRA
5KRC
5KRF
5KRH
5KRI
5KRJ
5KRK
5KRL
5KRM
5KRO
5N10
5T0X
5T1Z
5T92
5T97
5TLD
5TLF
5TLG
5TLL
5TLM
5TLO
5TLP
5TLT
5TLU
5TLV
5TLX
5TLY
5TM1
5TM2
5TM3
5TM4
5TM5
5TM6
5TM7
5TM8
5TM9
5TML
5TMM
5TMO
5TMQ
5TMR
5TMS
5TMT
5TMU
5TMV
5TMW
5TMZ
5TN1
5TN3
5TN4
5TN5
5TN6
5TN7
5TN8
5TN9
5TNB
5U2B
5U2D
5UF9
5UFW
5UFX
5W9C
5W9D
5WGD
5WGQ
6B0F
6C42
6CBZ
6CHW
6CHZ
6CZN
6D0F
6DF6
6DFN
6HHP
6HKB
6HKF
6HMU
6IAR
6OWC
6PET
6PFM
6PIT
6PSJ
6SBO
6SQ0
6SUO
6TL3
6V87
6V8T
6VGH
6VIG
6VJ1
6VJD
6VMU
6VNN
6VPF
6VPK
6VVP
6WOK
7JHD
7KBS
7KCA
7KCD
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