DCD DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues. Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG. Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.-.-; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 12q13.2
Cellular Component:  extracellular region
Molecular Function:  peptidase activity; protein binding
Biological Process:  antimicrobial humoral response; defense response to bacterium; defense response to fungus; killing of cells of other organism; proteolysis
Reference #:  P81605 (UniProtKB)
Alt. Names/Synonyms: AIDD; DCD; DCD-1; Dermcidin; diffusible survival/evasion peptide; DSEP; HCAP; MGC71930; PIF; Preproteolysin; proteolysis inducing factor; survival promoting peptide; Survival-promoting peptide
Gene Symbols: DCD
Molecular weight: 11,284 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene