ADIRF Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin. Up-regulated during pre-adipocyte differentiation. Up- regulated following DNA damage induced by UV irradiation.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 10q23.2
Cellular Component:  cytosol; nucleoplasm; nucleus
Biological Process:  cell differentiation; cellular response to cisplatin; cellular response to radiation; positive regulation of fat cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of response to drug
Reference #:  Q15847 (UniProtKB)
Alt. Names/Synonyms: Adipogenesis regulatory factor; Adipose most abundant gene transcript 2 protein; adipose specific 2; Adipose-specific protein 2; ADIRF; AFRO; apM-2; APM2; C10orf116
Gene Symbols: ADIRF
Molecular weight: 7,855 Da
Basal Isoelectric point: 5.17  Predict pI for various phosphorylation states
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ADIRF

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene