ADIRF Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin. Expressed in adipose tissue (at protein level). Highly expressed in omental and subcutaneous adipose tissues. Expressed in heart, cornea, liver, kidney and spleen. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 10q23.2
Cellular Component:  cytosol; nucleoplasm; nucleus
Biological Process:  cell differentiation; cellular response to cisplatin; cellular response to radiation; positive regulation of fat cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of response to drug
Reference #:  Q15847 (UniProtKB)
Alt. Names/Synonyms: Adipogenesis factor rich in obesity; Adipogenesis regulatory factor; Adipose most abundant gene transcript 2 protein; adipose specific 2; Adipose-specific protein 2; ADIRF; AFRO; apM-2; APM2; C10orf116
Gene Symbols: ADIRF
Molecular weight: 7,855 Da
Basal Isoelectric point: 5.17  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene