IQGAP2 Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. Isoform 2 expression is enhanced in testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5q13.3
Cellular Component:  actin cytoskeleton; cell surface; cytoplasm; cytosol; filopodium; lamellipodium; microvillus; plasma membrane; secretory granule membrane
Molecular Function:  actin binding; actin filament binding; Arp2/3 complex binding; calmodulin binding; GTPase inhibitor activity; phosphatidylinositol-3,4,5-trisphosphate binding; Rac GTPase binding; Rho GTPase binding
Biological Process:  Arp2/3 complex-mediated actin nucleation; negative regulation of GTPase activity; neutrophil degranulation; signal transduction; thrombin-activated receptor signaling pathway
Reference #:  Q13576 (UniProtKB)
Alt. Names/Synonyms: IQ motif containing GTPase activating protein 2; IQGA2; IQGAP2; Ras GTPase-activating-like protein IQGAP2
Gene Symbols: IQGAP2
Molecular weight: 180,578 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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IQGAP2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene