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IQGAP2
Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. Isoform 2 expression is enhanced in testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 5q13.3 |
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Cellular Component:
actin cytoskeleton; cell cortex; cell surface; cytoplasm; cytosol; filopodium; lamellipodium; microvillus; plasma membrane; secretory granule membrane
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Molecular Function:
actin binding; actin filament binding; Arp2/3 complex binding; calmodulin binding; GTPase activator activity; GTPase inhibitor activity; phosphatidylinositol-3,4,5-trisphosphate binding; small GTPase binding
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Biological Process:
Arp2/3 complex-mediated actin nucleation; mitotic actomyosin contractile ring assembly actin filament organization; regulation of actin cytoskeleton organization; regulation of GTPase activity; signal transduction; thrombin-activated receptor signaling pathway
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Reference #:
Q13576
(UniProtKB)
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Alt. Names/Synonyms: IQ motif containing GTPase activating protein 2; IQGA2; IQGAP2; Ras GTPase-activating-like protein IQGAP2
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Gene Symbols: IQGAP2
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Molecular weight:
180,578 Da
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Basal Isoelectric point:
5.47
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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